Science-Driven. Patent-Protected. Clinically Relevant.

Cell Tereo introduces the first cryopreservation technology engineered to shield biological samples from natural and cosmic radiation — Our patented system protects every stored cell so it remains as safe and functional years later as the day it was frozen.

1. Frozen stem cells continue to accumulate DNA damage during storage.

Despite being metabolically inactive, cells exposed to natural background radiation showed:

• Increased γ-H2AX foci (a marker of double-strand DNA breaks)

• Accumulation of unrepaired lesions

• Higher genomic instability over time

The Scientific Breakthrough Behind Our Technology

In 2022, our scientific team—led by Dr. Pierre Rocheteau, Dr. Fabrice Piquemal, and collaborators from CNRS and Institut Pasteur—published a groundbreaking peer-reviewed study in Cell Transplantation: “Cryopreserved Stem Cells Incur Damages Due to Terrestrial Cosmic Rays Impairing Their Integrity Upon Long-Term Storage.”

2. Radiation is the primary driver of these long-term DNA lesions.

The researchers compared cells stored:

• At ground level

• Under shielding

• Deep underground in the ultra-low-radiation facility at LSM Modane

Cells stored underground—protected from cosmic rays—displayed significantly fewer DNA breaks and better post-thaw functionality.

3. Damage affects viability, proliferation, and therapeutic potential.

Cryopreserved stem cells exposed to radiation showed:

• Lower survival after thawing

• Reduced ability to divide

• Potential functional decline relevant for regenerative therapies

This discovery provided direct scientific evidence that cryopreservation tanks and biobanks must consider radiation as a key degradation factor —

a problem Cell Tereo is purpose-built to solve.

For the first time, the study demonstrated that: